CHM 395-01 - Advanced Special Topic: Enzyme Engineering

4 credits (Spring)

The application of enzymes to catalyze selective organic reactions is a sustainable approach to synthetic chemistry. This multidisciplinary course will investigate classic and cutting-edge approaches to re-engineering natural enzymes to create suitable catalysts for abiological reactions and new metabolic pathways. Exemplary enzymes will include those containing metal/organic cofactors. In the laboratory, students will learn techniques that enable laboratory evolution of enzymes and apply those techniques evolve an enzyme as part of an independent research project.

Prerequisite: BIO 251 and CHM 222.
Instructor: Key